EVENODD: An Efficient Scheme for Tolerating Double Disk Failures in RAID Architectures

We present a novel method, that we call EVENODD, for tolerating up to two disk failures in RAID architectures. EVENODD employs the addition of only two redundant disks and consists of simple exclusive-OR computations. This redundant storage is optimal, in the sense that two failed disks cannot be retrieved with less than two redundant disks. A major advantage of EVENODD is that it only requires parity hardware, which is typically present in standard RAID-5 controllers. Hence, EVENODD can be implemented on standard RAID-5 controllers without any hardware changes. The most commonly used scheme that employes optimal redundant storage (i.e., two extra disks) is based on Reed-Solomon (RS) error-correcting codes. This scheme requires computation over finite fields and results in a more complex implementation. For example, we show that the complexity of implementing EVENODD in a disk array with 15 disks is about 50% of the one required when using the RS scheme. The new scheme is not limited to RAID architectures: it can be used in any system requiring large symbols and relatively short codes, for instance, in multitrack magnetic recording. To this end, we also present a decoding algorithm for one column (track) in error

Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data

Background: CT perfusion (CTP) and diffusion or perfusion MRI might assist patient selection for endovascular thrombectomy. We aimed to establish whether imaging assessments of irreversibly injured ischaemic core and potentially salvageable penumbra volumes were associated with functional outcome and whether they interacted with the treatment effect of endovascular thrombectomy on functional outcome. Methods: In this systematic review and meta-analysis, the HERMES collaboration pooled patient-level data from all randomised controlled trials that compared endovascular thrombectomy (predominantly using stent retrievers) with standard medical therapy in patients with anterior circulation ischaemic stroke, published in PubMed from Jan 1, 2010, to May 31, 2017. The primary endpoint was functional outcome, assessed by the modified Rankin Scale (mRS) at 90 days after stroke. Ischaemic core was estimated, before treatment with either endovascular thrombectomy or standard medical therapy, by CTP as relative cerebral blood flow less than 30% of normal brain blood flow or by MRI as an apparent diffusion coefficient less than 620 μm2/s. Critically hypoperfused tissue was estimated as the volume of tissue with a CTP time to maximum longer than 6 s. Mismatch volume (ie, the estimated penumbral volume) was calculated as critically hypoperfused tissue volume minus ischaemic core volume. The association of ischaemic core and penumbral volumes with 90-day mRS score was analysed with multivariable logistic regression (functional independence, defined as mRS score 0–2) and ordinal logistic regression (functional improvement by at least one mRS category) in all patients and in a subset of those with more than 50% endovascular reperfusion, adjusted for baseline prognostic variables. The meta-analysis was prospectively designed by the HERMES executive committee, but not registered. Findings: We identified seven studies with 1764 patients, all of which were included in the meta-analysis. CTP was available and assessable for 591 (34%) patients and diffusion MRI for 309 (18%) patients. Functional independence was worse in patients who had CTP versus those who had diffusion MRI, after adjustment for ischaemic core volume (odds ratio [OR] 0·47 [95% CI 0·30–0·72], p=0·0007), so the imaging modalities were not pooled. Increasing ischaemic core volume was associated with reduced likelihood of functional independence (CTP OR 0·77 [0·69–0·86] per 10 mL, pinteraction=0·29; diffusion MRI OR 0·87 [0·81–0·94] per 10 mL, pinteraction=0·94). Mismatch volume, examined only in the CTP group because of the small numbers of patients who had perfusion MRI, was not associated with either functional independence or functional improvement. In patients with CTP with more than 50% endovascular reperfusion (n=186), age, ischaemic core volume, and imaging-to-reperfusion time were independently associated with functional improvement. Risk of bias between studies was generally low. Interpretation: Estimated ischaemic core volume was independently associated with functional independence and functional improvement but did not modify the treatment benefit of endovascular thrombectomy over standard medical therapy for improved functional outcome. Combining ischaemic core volume with age and expected imaging-to-reperfusion time will improve assessment of prognosis and might inform endovascular thrombectomy treatment decisions. Funding: Medtronic

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

CHEP04

In this talk, we will discuss the future of storage systems. In particular, we will focus on several big challenges which we are facing in storage, such as being able to build, manage and backup really massive storage systems, being able to find information of interest, being able to do long-term archival of data, and so on. We also present ideas and research being done to address these challenges, and provide a perspective on how we expect these challenges to be resolved as we go forward

Ray-reps for Free-form Modeling: Line Membership Classification on CSRs

Low degree (typically 2, 3) tetrahedral implicit algebraic patches are gaining in popularity for modeling boundaries of free-form (sculptured) solids. A Constructive Shell Representation (CSR) is a union of truncated tetrahedra, called "trunctets", that form a thick shell containing the boundary of such a free-form solid. One bounding face of each trunctet is an algebraic patch, and the other faces are planes belonging to the associated tetrahedron. Recently, ray representations (ray-reps) have been shown to be extremely versatile for solid modeling, particularly when computed on the RayCasting Engine (RCE) -- a highly parallel customVLSI computer for CSG processing. A ray-rep is the set of "in" segments resulting from the classification of a grid of parallel rays against a solid. This paper merges the CSR and ray-rep streams of research and shows how CSRs can be processed directly to produce ray-reps. The algorithm developed here exploits the hybrid Brep/CSG character of CSRs, and use..

Disk Array Storage System Reliability

Fault tolerance requirements for near term disk array storage systems are analyzed. The excellent reliability provided by RAID Level 5 data organization is seen to be insufficient for these systems. We consider various alternatives -- improved MTBF and MTTR times as well as smaller reliability groups and increased numbers of check disks per group -- to obtain the necessary improved reliability. The paper begins by introducing two data organization schemes based on maximum distance separable error correcting codes. Several figures of merit are calculated using a standard Markov failure and repair model for these organizations. Based on these results, the multiple check disk approach to improved reliability is an excellent option. 1 Introduction Disk array storage systems, especially those with redundant array of independent disks (RAID) Level 5 data organization [13], provide excellent cost, run-time performance as well as reliability and will meet the needs of computing systems for th..